In this months Clinical Microbiology Reviews 2012, 25;(1):164-92, Dogget and co-workers review the unexplained worldwide resurgence in Cimex lecticularis (Bed bugs) blood sucking insects. Unless the bug burden is very high they may not always be visible. They can cause skin lesions which may mimic urticaria and other forms of dermatitis. Proteins from their gut wall are allergenic in humans and may cause asthma symptoms akin to more common dust mite. Skin test reactivity to their allergens has been described. Sounds disgusting ! but the author has seen at least one case last year where asthma was triggered by these insects.